Effect of silver nanoparticles on human mesenchymal stem cell differentiation

• Christina Sengstock,
• Jörg Diendorf,
• Matthias Epple,
• Thomas A. Schildhauer and
• Manfred Köller

Beilstein J. Nanotechnol. 2014, 5, 2058–2069, doi:10.3762/bjnano.5.214

• -toxic concentrations. Therefore, more studies are needed to investigate the effects of silver species on cells at low concentrations during long-term treatment. Keywords: differentiation; differentiation marker; mesenchymal stem cells; nanoparticles; silver; Introduction Novel nanomaterials are being

• absence of silver. The asterisks (*) indicate significant differences in comparison to the control (*p < 0.05;**p < 0.005). Release of the adipogenic differentiation marker adiponectin after hMSCs were incubated with Ag-NP/Ag+ ions. After incubation with different concentrations of Ag-NP/Ag+ ions for 24 h

• respect to to the control (*p < 0.05; **p < 0.005). Release of the osteogenic differentiation marker osteocalcin after incubation of hMSCs with Ag-NP/Ag+ ions. The data are expressed as the mean ± SD (n = 7 independent experiments), given as the percent of the control (osteocalcin 15.6 ± 6 ng·mL−1; cells

Carbon-based smart nanomaterials in biomedicine and neuroengineering

• Antonina M. Monaco and
• Michele Giugliano

Beilstein J. Nanotechnol. 2014, 5, 1849–1863, doi:10.3762/bjnano.5.196

• transformation into myofibroblasts. Their results showed an up-regulated expression of a specific differentiation marker, accompanied, however, by an increased generation of the most biologically significant free radicals, the reactive oxygen species (ROS). NDs: Among the applications of NDs, the most important